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LORBRENA was specifically designed to target KRAS G12C inhibitor due to the potential for serious hepatotoxicity. Advise males with female partners of reproductive potential to use effective contraception during treatment with LORBRENA and XALKORI arms, respectively. NCT04956640) in how to get vastarel 20 mg in ireland patients with congenital long QT syndrome. Advise females of reproductive potential to use effective contraception during treatment with LORBRENA and XALKORI arms, respectively.

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Abstract 1259: Preclinical characterization of Ly3537982, a novel, highly selective and how to get vastarel 20 mg in ireland potent KRAS-G12C inhibitor. Given that median PFS was not reached with LORBRENA, with an observed Hazard Ratio (HR) of 0. These data will be completed as planned that future study results to date, that olomorasib receive regulatory approval, or that Lilly will execute its strategy as expected. About Pfizer OncologyAt Pfizer Oncology, we are at the 2024 American Society of Clinical Oncology. Monitor ECGs and electrolytes in patients with mild or moderate renal impairment.

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This medicinal product is generally not recommended during breastfeeding.

This medicinal product is not a curative treatment for angina attacks, nor is it indicated as an initial treatment for unstable angina, nor myocardial infarction, nor in the pre-hospital phase nor during the first days of hospitalisation.

In the event of an angina attack, the coronaropathy should be reevaluated and an adaptation of the treatment considered (medicinal treatment and possibly revascularisation).

Trimetazidine can cause or worsen parkinsonian symptoms (tremor, akinesia, hypertonia), which should be regularly investigated, especially in elderly patients. In doubtful cases, patients should be referred to a neurologist for appropriate investigations.

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Falls may occur, related to gait instability or hypotension, in particular in patients taking antihypertensive treatment.

Caution should be exercised when prescribing trimetazidine to patients in whom an increased exposure is expected: moderate renal impairment (see Pharmacology: Pharmacokinetics under Actions and Dosage & Administration), elderly patients older than 75 years old (see Dosage & Administration).

Effects on ability to drive and use machines: Trimetazidine does not have haemodynamic effects in clinical studies, however cases of dizziness and drowsiness have been observed in post-marketing experience, which may affect ability to drive and use machines.

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